British two-time Champion, Andy Murray lost in four sets against American John Isner in the second round of Wimbledon.
Murray clinched the third set but fell 6-4 7-6 (7-4) 6-7 (3-7) 6-4 to the big-hitting 20th seed.
He will play Italian 10th seed Jannik Sinner next.
Murray had never before failed to reach the third round at SW19, in 13 previous attempts.